Ibogaine neurotoxicity assessment: electrophysiological, neurochemical, and neurohistological methods.
نویسندگان
چکیده
منابع مشابه
Interactions between ibogaine and cocaine in rats: in vivo microdialysis and motor behavior.
To investigate a possible basis for the proposed anti-addictive property of ibogaine, the effects of an ibogaine (40 mg/kg i.p.) pretreatment on in vivo neurochemical and motor effects induced by cocaine (20 mg/kg i.p.) were studied. Ibogaine, administered 19 h earlier, potentiated the increase in extracellular dopamine levels in striatum and nucleus accumbens as well as the stimulated motor ac...
متن کاملHow toxic is ibogaine?
CONTEXT Ibogaine is a psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe Iboga. It is unlicensed but used in the treatment of drug and alcohol addiction. However, reports of ibogaine's toxicity are cause for concern. OBJECTIVES To review ibogaine's pharmacokinetics and pharmacodynamics, mechanisms of action and reported toxicity. METHODS A search of the literatur...
متن کاملIbogaine neurotoxicity: a re-evaluation.
Ibogaine is claimed to be an effective treatment for opiate and stimulant addiction. O'Hearn and Molliver, however, showed that ibogaine causes degeneration of cerebellar Purkinje cells in rats. The present study re-examined cerebellar responses to the high doses of ibogaine used by O'Hearn and Molliver (100 mg/kg or 3 x 100 mg/kg) and sought to determine whether a lower dose (40 mg/kg), one ef...
متن کاملThe anti-addictive drug ibogaine modulates voltage-gated ion channels and may trigger cardiac arrhythmias
Background Ibogaine is an alkaloid derived from the African shrub Tabernanthe iboga. Psychoactive properties of ibogaine have been known for decades, but more recently the drug has received much attention because of its promising “anti-addictive” actions. Thus, ibogaine and its derivatives are being studied as potential treatment for opioid and stimulant abuse, as well as for alcoholism and smo...
متن کاملDifferential effects of ibogaine pretreatment on brain levels of morphine and (+)-amphetamine.
Previous studies in rats have shown that ibogaine inhibits neurochemical and behavioral effects of morphine yet potentiates similar effects of (+)-amphetamine. To assess whether these different functional interactions have a metabolic basis, brain levels of morphine and (+)-amphetamine were measured by gas chromatography-mass spectrometry after ibogaine pretreatment (19 h before injection of mo...
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ورودعنوان ژورنال:
- The Alkaloids. Chemistry and biology
دوره 56 شماره
صفحات -
تاریخ انتشار 2001